step 3.3. Chance Facts
Compared with men with BMI? 25 kg/m 2 , the age-adjusted risk of osteoporosis was over four-fold higher in those with BMI < 25 (odds ratio (OR) 4.4 (1.51, ) in age-adjusted model (Table 3). The association between BMI and osteopenia was similar among overweight/obese and normal weight men, although not statistically significant (Table 3).
One another Bmi and lbs was basically synchronised which have BMD, and you may BMC indications plus the most powerful Pearson’s relationship coefficients was in fact discover ranging from pounds and you will BMC altogether cool and you will trochanter nations and you will new weakest of these have been between Bmi and you may femoral neck BMC. The newest correlations anywhere between many years and BMD and BMC signs was in fact bad (Desk 4).
Age-adjusted proportion regarding BMD and you may BMC type explained from the Body mass index and you will pounds is actually revealed within the Table 5. Weight tended to inform you higher differences in BMD and you can BMC distribution after all brand new examined skeletal websites than the Body mass index. This is reflected by the steeper hill (?) of particular linear regression lines. Best difference in BMD and you may BMC delivery appeared in the trochanter BMC followed by lumbar BMC for pounds. Weight is a vital predictor off BMD and you can BMC variation for the earlier Iranian males.
4. Conversation
In this study, both BMI and weight were associated with BMD, and obesity significantly decreased the risk for osteoporosis in men. These results are consistent with most previous studies, particularly in postmenopausal women, which indicated that lower BMI and weight were associated with lower BMD. Prospective studies found that the early postmenopausal women who have low BMI lose more bones compared to those with higher BMI tertiles [4, 8]. In other cross-sectional studies, however, thinness is related to both osteoporosis and increased fracture risk [10, 11]. Iqbal et al. found that low BMI is a good indicator for referral of women less than 60 years old for measurements of BMD. Similar studies also reported a consistent finding that lower BMI was associated with lower BMD [5, 6, 28]. In a study similar to ours, those with lower BMI were at higher risk of low BMD . The Studies of National Osteoporosis Foundation and others suggested that low BMI should be included in the risk assessment tools for evaluation of osteoporosis and osteoporotic fracture risk [29–31]. We found that men with BMI < 25 had 4.4 (95% CI 1.5, 12.8) times higher age-adjusted risk of osteoporosis than men with BMI ? 25. In contrast, Steinschneider et al. in a cross-sectional study reported that the correlation between BMD at the femoral neck and BMI was highly positive among postmenopausal women. A hospital-based study conducted in elderly men reported that overweight and obese men were more likely to have osteoporosis and osteopenia . The possible explanation for the discrepancies between these results might be related to populations, research designs, sampling methods, and methodological differences.
The latest elements wherein fat exerts positive effects into the BMD standing are not completely obvious. The fresh putative mechanism significance regarding fat for skeletal integrity probably resides in brand new role of many adipokines inside bone restorations using influence on both development and you can resorption. Has just, limbs might have been noticed a keen endocrine organ affecting body weight handle and you may glucose homoeostasis from the strategies out-of bone-derived facts such as for example osteocalcin and you can osteopontin [23, 34–36]. The fresh putative crosstalk between body weight in addition to bones comprises a homoeostatic viewpoints system where adipokines and you may particles produced of the osteoblasts and you may osteoclasts represent the hyperlink of a dynamic bone-adipose axis [34–36]. Obesity is additionally associated with the BMD of the conversion process from androgen to the hormone estrogen , and therefore enhances bones mass in folk [38, hoe gebruik je adultspace 39] and you can maintains suit plasma quantities of insulin and managing affairs plus insulin-such progress factor-1, leptin, and adiponectin . At exactly the same time, carrying excess fat will bring padding towards the cool in the event of a slip . But not, new mechanisms whereby all these situations exists are nevertheless not sure.
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